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DIABETES
MELLITUS TYPE 2 (Non-Insulin Dependent)
S/O
|
Assessment
|
Plan
|
|||
Problem:
S/O evidence |
Etiology |
Evaluation
for Need of Therapy |
Recommended
Therapy |
Goals/Monitoring
Parameters |
Patient Education |
Subjective: -
Gradual
and maybe w/o symptoms -
Obesity -
Weight
changes -
Fatigue
due to dehydration -
Pruritus -
Polyphagia(hunger) -
Polydipsia
(thirst) -
Polyuria
-
Suseptible
to infections Objective: -
FFG
³
126mg/dL -
2hrPPG
³200mg/dL -
HbA1c
> 7% -
BP³
140/90 mmHg |
Risk
Factors: -
Age
> 40yrs -
Family
Hx of DM2 -
Smoking -
Obesity -
HTN -
CAD -
Alcoholic |
-
Test
Blood GlucoseG q3yrs after age of 45 -
Test
BG in those who are high risk: 1)
obese 2)
BP ³
140/90 3)TG
³
250mg/dl 4)
Ethnic (asian, blacks, Hispanic) |
Non-Pharmacologic:
(3 months) -
Diet
(low fat, carbohydrate, salt) -
Exercise
(3-5 times a week) -
Goal:
FPG < 126mg/dl; HbA1c <7% *If gylcemic
goal not achieved after 4-8wks (FPG . 140mg/dl; HbA1c >8) à
Drug
Pharmacologic: -
Monotherapy: 1st
Line:
-
Sulfonylurea(lean
and insulinopenic) -
Metformin
(overweight or dyslipidemic, insulin resistence): 500mg BID 2nd
Line: -
Thiazolidinediones
(insulin resist. Or renal impaired) -
Acarbose
(PostPrand. Hyperglycemic): 25mg TID -
Meglitinides
(Erratic meals, renal impairment) -
Insulin
may be considered if very symptomatic.
*If Glycemic goal not achieved after 4- 8wks: -
Combination
therapy: Add
2nd Oral agent: -
Sulfonylurea
+ metformin -
Sulfonylurea
+ TZDs Or
-
if
Post Prandial hyperglycemia: Sulfonylurea
+ acarbose Or -
Add
insulin at QHS or BID
Dose: 0.7-2.5 U/kg/day
*If Glycemic goal not achieved: -
Additional
: -
Add
Insulin qhs -
Add
3rd Oral agent -
Switch
to insulin monotherapy -
Consider
referral to specialist |
Goals: -
PPG:
90-130mg/dl -
QHS
PG: 110-150mg/dl -
HbA1c:
< 7% -
FPG
< 126mg/dl Monitor: -
Blood
glucose -
Adverse
Effects -
Weight -
BP -
HbA1c -
Secondary
diabetic conditions (retinopathy, neuropathy, etc.) - Foot care -
Drug
interactions |
- Daily Glucose monitoring - Stop smoking - Stop Drinking alcohol -
Low fat diet - Low carbohydrate diet - Low salt diet - BP control - Daily Exercise |
Hypoglycemic Agents
Class: |
Agents/Dosage
Forms/Dosing: |
Indications/
MOA: |
PK: |
Adverse
Effects |
Drug
Interactions/ Contraindications |
Patient
Education |
Sulfonylurea |
1st
Gen: Chlorpropamide
(Diabeinese 100mg, 25mg): 100-500mg QD
Tolazamide
(Tolinase 100,250,500mg):200-1000mg QD-BID
Tolbutamide(Orinase
250,500): 500-3000mg BID-TID
2nd
Gen: Glipizide
(Glucotrol 5,10mg): 2.5-40mg
QD-BID
Glipizide
extended release (Glucotrol XL 5,10mg):
5-20mg QD
Glyburide
(Diabeta, Micronase 1.25,2.5, 5mg): 1.25-20mg
QD
Micronized
Glyburide (Glynase, PresTab 1.5, 3, 6mg):
1-12mg QD
3rd
Gen: Glimepiride
(Amaryl 1,2, 4mg): 1-8mg QD |
*
For Type 2 DM
* New onset disease (<5yrs) *
Mild hyperglycemia
*
Normal weight to mild obesity MOA:
Primary: Stimulate release
insulin release from Beta cells of pancreas
Secondary:
-
inhibit glucagon release
-
increase insulin Receptor binding affinity
- Increase insulin’s effect by post receptor action
-
decrease hepatic insulin extraction |
|
Hypoglycemia
Weight
gain
GI: Nausea, fullness, indigestion - take with food if happens
(except for glipizide-empty stomach only)
Hematologic: anemia, leukopenia
Disulfiram-like Rxn: Alcohol-related
flush, HA, Lightheadedness, N/V - mainly with chlorproamide
Hyponatremia/Syndrome of Inappropriate Anti-diuretic Hormone:
incr H2O intake
Dermatologic: rash |
1st
Gen: are highly
protei(albumin) bound, interxn with other highly protein bound drugs(ie.
Warfarin, aspirin, sulfonamide, phenyl butazone, clofibrate,
chloramphenicol) CI: Type
I DM
Pregnancy
Hypersenstivity
Rxn
Severe
Hepatic/Renal Dysfunc
Severe
illness,surgery, stress |
Common
SE: GI (constipation/diarrhea
heartburn, lack appetite)
May cause alcohol intolerance
May have skin rxn Make sensitive to sun
If forget to take a dose, take as soon as remember;
Do not double up if too close to next dose |
Meglitinides |
Repaglinide
(Prandin 0.5, 1, 2mg): 0.5-4mg
before meals: Max 16mg/day Nateglidine
(Starlix-Norvartis) |
*FDA
approved for monotherapeutic use and for use in combination with metformin
Good for ESRD MOA: A benzoic acid derivative; A nonsulfonylurea insulinotropic
agent; Like sulfonylurea,
stimulates insulin release from B-cells
Is Glucose dependent and is reduced at low glucose conc |
Excreted
in bile/ No active metabolites |
Hypoglycemia-
less severe than sulfonylureas
Weight gain
Hematologic: thrombocytopenia; leukopenia
Hepatic: elevated LFTs |
DI: Is
metabolized by CYP450 isozymes - affected by inducers and inhibitors CI: Same
as above
|
Take
before meals 15-30mins; If
skip a meal, skip a dose; Add
a meal, add a dose for that meal. |
Alpha-glucosidase |
Acarbose(Precose
25,50,100 mg): 25-300mg/d QD-TID
Miglitol
(Glyset 25,50,100mg): 25-100mg/d
QD-TID |
*
A monotherapy +MNT / exercise
* Adjunct therapy with insulin/sulfonylureas in Type 2 DM(non-FDA) * Adj with insulin with Type I DM to reduce
insulin dosage(non-FDA) MOA: A complex oligosac that competively inhibits intestinal
enz; of small intestine. Delays
intestinal conversion of SUCROSE to glucose/fructose;
Delays starch digestion;
NO effect on absorption of Glucose, Lactose, or Dextrose;
No effect on Weight gain/lipids |
<
1% systemic absorption; Fecal
elimination, degraded by GI microorganism. |
GI:
flatulence, ab distention, diarrhea
Hepatic: reversible incr in LFTs |
DI: Metformin:
decr absorption of Metformin;
Chlestyramine: enhance effect by acarbose
Miglitol: decr
levels of ranitidine/propanolol CI:
Type I DM; Pregnancy /lactating. GI disorders; Pts with cirrhosis; Renal impairmt (SCr>2);
Hypersensitivity rxn
Severe
illness, surgery or stress |
GI
side effects- take with meals; Have
metallic taste
Combo therapy with insulin-hypoglycemia risk
Cause weight lost
Decrease Lipid levels |
Biguanides |
Metformin
(Glucophage 500, 850, 1000mg): 500-2550
mg BID-TID |
MOA:
Decrease hepatic glucose output;
Increase peripheral insulin sensivity in skeletal muscle. |
T
½ = 3 hrs Duration:
6-12hrs Renal
Elimination; Dialyzable |
GI:
Nausea, bloating, cramping, diarrhea CNS:
H/A, agitation, dizziness, tiredness
Lactic Acidosis:rare
Malabsorption: B12 and folic acid
|
DI: Cimetidine competes with Metformin at renal tubule
inhibiting its clearance and increase availability CI: Renal impairmt: SCr>1.5mg/dl males;
SCr>1.4 mg/dl females
Hepatic dysfunc Alcoholism
; Lactic acidosis
Acute conditions: MI,CHF, infections, trauma, surgery |
GI
side effects- take with meals; Have
metallic taste; Combo therapy with insulin-hypoglycemia risk;
Cause weight lost; Decrease Lipid levels |
Thiazolidinedione |
Rosiglitazone
(Avandia 2,4,8mg): 4-8mg/d QD-BID
Pioglitazone
(Actos 15,30,45mg): 15-45mg/d QD
Troglitazone (Rezulin)-(off the market) |
MOA:
Decrease insulin resistance; Increase
insulin sensitivy in hepatic, muscle and adipose tissue;
Decrease Hepatic glucose output. |
T
½ = 3-7hrs Hepatically
metabolized; Eliminate in
urine/feces. Absorption peak
at 2 hrs. |
Hepatic:
LFTs, reversible jaundice; idiosyncratic drug rxn
Hypoglycemia: combo therapy |
CI:
Hypersenstivity or allergy
Hepatic impairment |
If
dose missed at usual meal, take at next meal; Combo therapy: risk
of hypoglycemia;
Reduce effectiveness in Oral ontraceptives |
*Use these information at your own discretion. I compiled the information from various sources. Please don't hold me to it if the information is wrong. If there are some mistakes...please email me and tell me. Thanks.